As a vaccine carrier, adenovirus has the advantages of wide host range, low pathogenicity to humans, homology with human genes, effective proliferation and high titer. It is one of the most promising new vaccine vectors. Under the leadership of Researcher Zhou Dongming, the Anti-Infection Immunization and Vaccine Research Group of Shanghai Pasteur Institute is committed to the research and development of new vaccine carriers, universal influenza vaccines and related immunological research. Recently, they and the Wistar Institute researchers have made new progress in the cooperative research on adenovirus as a vaccine carrier. The research results are titled Hexon-modified Recombinant E1-deleted Adenovirus Vectors as Dual Specificity Vaccine Carriers for Influenza Virus International academic journal "Molecular Therapy" (Molecular Therapy). In the study, they cloned the M2e gene of influenza virus H1N1 into the Hexon R1 or R4 region based on the E1 deleted chimpanzee adenovirus AdC68 vector, and combined the three M2e genes of H1N1, H5N1 and H7N2 and the NP gene of H1N1 It was cloned in the E1 deletion region of the modified adenovirus vector of Hexon, and obtained a variety of recombinant adenoviruses that simultaneously expressed foreign genes in the Hexon variable region and E1 deletion region. After immunizing animals, it was found that the modified double expression vector of Hexon R1 can induce high-strength, high-affinity specific antibodies, and it has a good immune protection effect against the lethal dose of influenza virus attack infection; double expression of Hexon R4 The immune effect of the carrier is relatively low. This study clarified the new biological and immunological characteristics of adenovirus, and further optimized the adenovirus vector, which has important guiding significance for the design and evaluation of new vaccine vectors, and also provides a new universal influenza vaccine development. A new strategy. The research was supported by a number of grants from the National Natural Science Foundation General Project, the NIH of the United States, and the Pennsylvania State Government. Figure 1: Construction of adenovirus double expression vector modified by Hexon Give Yourself The Comfort You Deserve With WIC KLES Electric Recliner Sofa With USB Port! Electric Recliner Sofa, Electric Recliners,Power Recliner Sofa Set,Electric Reclining Sofa Kaifeng Lanwei Smart Home Co., Ltd , https://www.leather-recliner.com
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