New MRI detection of cartilage GAG ​​can diagnose osteoarthritis early

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"Daily Science" (2010-8-27)-New York University researchers have developed a new method to understand the development of knee osteoarthritis-that is, relying on the examination of sodium ions in articular cartilage. It can provide non-invasive examination methods for the diagnosis of early osteoarthritis, and their results are published in the Journal of Magnetic Resonance.

Sodium ions are dispersed in the body, and its concentration reveals the location of glycosaminoglycans (GAGs) in cartilage tissue. Glycosaminoglycan is a molecular substance that is the foundation of cartilage and also participates in many human life activities. Drawing a concentrated graph of glycosaminoglycans can not only determine the efficacy of drug treatment, but also help diagnose and monitor many diseases. For example, the loss of glycosaminoglycans in cartilage specifically indicates the onset of osteoarthritis and disc degeneration.

However, the current GAG inspection technology based on traditional MRI imaging has many limitations: it cannot directly map the concentration of GAG or it needs to use contrast agent to display the location of these concentrations. Since sodium ions already exist in the cartilage, the researchers tried to measure these sodium ions using a special, non-invasive MRI technique.

Previously, researchers at the University of Pennsylvania and Stanford University have developed such research methods. However, these methods cannot separate (or distinguish) ions in different parts of the knee joint. In particular, the slow-moving sodium ion signal in cartilage cannot be clearly distinguished from the free sodium ion signal in synovial fluid or joint exudate.

The research team at New York University tried to improve this method by focusing on the characteristics of sodium ions in two different environments.

Because sodium ions are not only present in cartilage, magnetic resonance imaging often fails to indicate whether it is a concentration of sodium ions in cartilage, or a concentration of sodium ions in other parts of the joint. To better indicate where these sodium ions are concentrated, the researchers focused on the magnetic behavior of sodium ions in different tissues. By using the characteristics of sodium ions in different tissues, this group of researchers successfully developed a new method to distinguish sodium ions in different tissues. As a result, such an image can be obtained that the sodium ion signal can be specifically displayed on the part where there is cartilage tissue.

This new MRI sodium imaging can not only provide a non-invasive diagnostic method for early osteoarthritis, but also help correct other articular cartilage evaluation methods.

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