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Relevant red fonts are the search engine optimization catalogue of Beijing equation biological Chinese medicine reference products, which has nothing to do with the content of this article Mouse PGF kit 48T box 5-hydroxymethylfurfural 20mg bottle Chicken serum 100ml bottle Notoginseng 20mg stick Mouse ELISA kit 96T box Mouse PEG2 kit 96T box 100u thrombin Mouse CFH kit 96T box One batch of inspection fees Filter 0.25 Gibco serum 500ml bottle Gibco medium 500ml bottle Human ANA kit 48T box Plant IAA kit 96T box Actinomycin D2mg Human GH kit 96T box Geniposide 20mg stick Approval of reference products Mouse CH50 kit 96T box Mouse CH50 kit 48T box D6904-0110 times box D6926-016 times box Collagen I1G branch Resveratrol 20mg stick 1g ampicillin Biological reagent 96T box Human PAF elisa kit 48T box CTAB 10KG barrel Monkey INS kit 96T box Human SOD detection kit 96T box Malondialdehyde detection kit 96T box Human GAD-Ab kit 48T box Human IAA kit 48T box 500ml bottle of fetal bovine serum treated with activated carbon Fish E2 kit 48T box SOD kit MN-SOD kit MDA kit CK kit Yesterday, June 18th, @ 香港 在线 relayed an emergency notice from the Hong Kong Department of Health on Sina Weibo. The original Weibo content is as follows: Urgent notice: The Department of Health today appealed to the public not to buy or take an oral product labeled "Vic C Yinqiao Tablet". The test results showed that the product contains two unlabeled and banned western medicine ingredients "Finaci Ding and Aminopyrine. This product has no record of being imported into Hong Kong for sale, nor has it applied for drug registration. These two drugs can relieve pain, but they can cause serious side effects and were banned in the 1980s. As of the time of publication, the number of Weibo reposts exceeded 13,000 times, and it was listed on the Weibo Hot Topics List. After seeing the original text of the emergency notice, Ent felt very strange: (Original notice) The link also stated that the Western medicine components VC, chlorpheniramine and acetaminophen marked by the VC Yinqiao tablets it detected were not found at all. In other words, if it is not a component of Chinese patent medicine, this is another medicine. But ... this is too exaggerated? A drug completely changed the formula, but it was not found out. How dare the manufacturer do this? These two ingredients are more powerful than the original formula for antipyretic and analgesic, but You are just a public face VC Yinqiao film, and it is not a special cold medicine brand that is vigorously promoted. Even if you take your medicine, the cold really disappears faster. Who can remember which one you are? If you replace it with this If the original ingredients are used to save costs, can you find out that the effective ingredients you marked are zero after a quality inspection? So I can't understand what happened ... for explanation ... in fact, I doubt the medicine bottle ... In this regard, the pharmaceutical squirrel window knocking rain gave the answer: The reason for this matter can only be further investigated ... I can provide some known information. The chemical ingredients contained in the approved VC Yinqiao tablets: each tablet contains 49.5 mg of vitamin C, 105 mg of acetaminophen, and 1.05 mg of chlorpheniramine maleate. Aminopyrine and phenacetin are obviously not allowed. This situation in the news is classified as a counterfeit drug according to the Drug Administration Law, and it can be considered as a counterfeit drug if it contains components of drugs other than those prescribed, regardless of the size of the hazard. It is a very serious quality problem. Other reasons than intentional addition are not ruled out, but it is still a quality problem (unless the problem lies with the patient, such as the use of other medicines in this bottle, this possibility does not feel very likely). What was discussed in this incident was not the safety of VC Yinqiao tablets, but the problem of illegally adding other ingredients. Qualified VC Yinqiao tablets should not have this problem, because this is a quality problem, not a problem of the nature of the drug itself. VC Yinqiao tablets are not good medicines, but the news reports generally say that VC Yinqiao tablets are actually very unfair to manufacturers that produce qualified drugs. Aminopyrine and phenacetin are indeed not completely prohibited on our side. For example, there is a relatively traditional antipyretic drug "APC" (compound aspirin tablets) that contains 150 mg of phenacetin, which is still not banned and can be found on the CFDA website. Aminopyrine is also a similar situation, the reason why there is no "total prohibition", such as the two links found by @ 游 识 猷, the first is that a test report in the National Drug Standards of the State Drug Administration clearly states "aminopyrine coffee" Because the tablet contains aminopyrine, in 2012, the “Notice of the State Food and Drug Administration on the cancellation of 106 drug approval numbers for Dangui Huoxue liquor, etc.†contained the compound acetylsalicylic acid containing phenacetin. Acid tablets (aspirin 0.22g, phenacetin 0.15g, caffeine 35mg) are impressively listed. However, their security problems do exist. As stated in the 35th edition of the "Martindale Drug Code": Precautions for adverse reactions: phenacetin may cause methemoglobinemia, thiohemoglobinemia, and hemolytic anemia. Long-term large-dose application of analgesics containing phenacetin will cause renal papillary necrosis and renal pelvis transitional cell carcinoma. Uses and usage: phenacetin is a derivative of p-aminoaminophenol with analgesic and antipyretic effects. It is often used in combination with aspirin, caffeine, or codeine, but it is now used sparingly because of its nephrotoxicity and adverse effects on blood. The actual situation is that although there is no prohibition, it is used less and less in China. Many doctors are very aware of their side effects. The World Health Organization (WHO) cited examples of adverse drug reactions in 2008 that mentioned aminopyrine: aminopyrine (for inflammation), corresponding to the adverse reaction: white blood cell disease. In fact, aminopyrine has a greater risk of agranulocytosis, which is the main reason why it is no longer recommended. The main reason is that now we have several safer antipyretic and analgesic drugs that can replace them, so there is no need to continue to use them. I think the ban on these ingredients is also based on this consideration. The core of the incident refers to the quality of medicines, so it should be followed up to continue the investigation. In addition, qualified products should not be involved in the report. The addition of ingredients that should not be added is a matter of the quality of the drugs on the board. Another question raised by this incident is whether there should be a clear dose of Western medicine ingredients in Chinese medicine? The answer is yes. The following is also the analysis from the window knocking rain. First of all, for legal drugs, there is a clear dose of Western medicine added to Chinese patent medicine. For example, VC Yinqiao tablets clearly stated in the manual: each tablet contains 49.5 mg of vitamin C, 105 mg of acetaminophen, and 1.05 mg of chlorpheniramine maleate. Calculated on the basis of two tablets three times a day, in fact, it is similar to the dosage of regular cold medicine. In Zhenju Jiangya tablets, clonidine hydrochloride 0.03mg and hydrochlorothiazide 5mg were added to each tablet. Why is it said that there are hidden dangers? The main problem is that there are no clear signs and reminders. We can look at the names of these proprietary Chinese medicines, whether they are "VC Yinqiao Tablets", "Zhenju Jiangya Tablets" or "Xiaoke Pills", from the name we simply cannot get accurate information on the ingredients of Western medicines added to them. If you do not look at the instructions carefully, you may not be able to find out which chemical ingredients are added, and treat it as a pure Chinese medicine. At this time, if you take a chemical drug containing similar drugs at the same time, it may cause an overdose of a certain chemical drug component, or the drug effects of similar drugs are superimposed, causing health problems. For example, if you take VC Yinqiao tablets when you have a cold, and then take other western medicine cold medicines or antipyretics, acetaminophen may overdose and cause acute liver damage. After taking Zhenju antihypertensive tablets and taking other antihypertensive drugs yourself, the blood pressure may become too low. Moreover, in the consciousness of many people, "Chinese medicine" is also used as a synonym for "safety", so there is not such a strong sense of dose control for Chinese patent medicines, and the dose may be increased more randomly, which will also cause trouble. The above is the case of legal drugs, illegal drugs are even more troublesome. Some drugs or health products that claim to have amazing effects may illegally add chemical drugs in order to really show their effects. For example, glucocorticoids may be added as a "miracle drug" for treating asthma. My teacher has encountered such cases. The patient claims to only eat Chinese medicine to control asthma, but at first glance it is a typical full moon face buffalo back. Side effects of inappropriate use of hormones. In this case, the dosage is really unknown, and the risk is quite large. And in this case, in order to save costs, usually add some cheaper drugs, but may have more side effects (such as hypoglycemic "magic drugs" often add glyburide, which is relatively easy to cause hypoglycemia A drug, and hypoglycemia is actually much more dangerous than hyperglycemia in the short term). I would like to say one more thing, if health care products are really effective in curing diseases, you must be vigilant. . . SFDA also issued a warning of Zhenju anti-hypertensive tablets some time ago: http: //WS01/CL0051/78803.html In general, even legal "Chinese and Western medicine combination" medicines can easily cause consumers to ignore the Western medicine ingredients and lead to repeated and excessive use of medicines, so there is a big health risk. General consumers must carefully read the drug instructions when using drugs. I personally feel that this kind of "Chinese and Western medicine make up" drugs are actually quite unnecessary, but now they will definitely not be withdrawn from the market immediately, so everyone should pay more attention. As for which Chinese patent medicines have added Western medicine, please borrow the picture edited by @ 人 å« è¯ on Weibo. In short, the closest to our lives may be various cold medicines:
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